The drama is set against the backdrop of drug-related cases. It tells the story of Zhang Zhuoying (Zuo Hang), a female policewoman from the anti-drug detachment, and Wang Xingjian (Wang Zirui), who loves advanced technology but has a casual personality, working undercover to fight drug dealers. The drama uses the investigation of the new drug C2, which is extremely harmful, as a clue to uncover a major drug case in which the older generation of drug-related police officers, including Zheng Xiao (Bai Yongcheng) and Zhang Xudong (Li Youbin), participated 24 years ago. With the full cooperation of two generations of public security police officers, they were trapped in danger and fought a life-and-death struggle with drug lords. In the end, they cracked a major drug trafficking and drug manufacturing case with C2 as the source, and the mastermind behind the scenes also surfaced.