In the ancient world, humans and demons coexisted. There was a clinic in the Three Realms that only treated demons and not humans. It was rumored that there were two people and one beast in the clinic. The shopkeeper, the doctor Hongniang, was charming, the assistant Sanchi was a sissy, and the servant Duoju (a toad spirit) had a human face and a demon body. The demon clinic, which was originally peaceful, fell into crisis due to the arrival of an uninvited guest, the scholar Jin Zhijian. The scholar's pregnancy was a strange story, but the demon turned out to be a rare demon pill. Hongniang wanted to deliver the baby and take the blood from the demon pill's heart to break the defect of her own fate. After a few days of careful care for the demon pill, the man and the beast developed a friendship. Hongniang decided to let the demon pill go, but was surrounded by the Xuanjia Gate. It turned out that everything was the plan of the head of the sect, Xiongkui. He wanted to use the blood from the demon pill's heart to cultivate the bloodthirsty rhododendron, and suck the blood of the demon clan to prolong his life. So far, Hongniang was in a desperate situation...