In the countryside of Texas, the old cowboy Moss (Josh Brolin) found several corpses, several packets of heroin and 2 million cash while hunting antelope. Moss decided to take the drugs and cash for himself, hoping to change his life, but he was tracked and hunted by the cold-blooded killer Chigurh (Javier Bardem) and fell into danger of fleeing. At the same time, the local sheriff Bell (Tommy Lee Jones) was also investigating a series of murders and trying to protect Moss's safety. However, what made Bell feel powerless and desperate was that he tried his best but could not track down the cold-blooded killer, and Moss's life safety was also seriously threatened. Bell remembered the glorious years of his fathers and felt deeply the sadness of being helpless in reality.