The sudden suicide of the Austrian crown prince has revived Holmes (Robert Downey Jr.), who has been silent for 6 months. This time, Holmes has a powerful opponent - Professor Moriarty (Jared Harris), who is as intelligent as Holmes. In order to investigate the suicide of the crown prince, Holmes and Watson (Jude Law), with the help of the gypsy astrologer Sim (Noomi Rapace), started a contest with Moriarty across the entire European continent, from Britain to France and Germany... Although he is known as the smartest person, Professor Moriarty seems to be able to predict Holmes' whereabouts and can escape before Holmes. The people on Professor Moriarty's death list were wiped out one by one, and history may be rewritten. How does Holmes deal with such a powerful opponent?