Frank (Nicolas Cage) is an administrator of a large animal sanctuary. This time, he participated in a very dangerous task, which was to escort a ship full of rare and dangerous large animals from Amazon to Greece. In addition to wild animals on the ship, there are more dangerous creatures, that is, the experienced and cunning killer Lafle (Kevin Durand). Sure enough, during the journey, Lafle got rid of the police in charge of guarding him and released the fierce and deadly beast in the cage. For a while, the ship fell into chaos. As the person in charge, Frank not only has to ensure that the wild animals are not harmed, but also shoulders the lives of the crew and hunts down dangerous fugitives.