Alice (Milla Jovovich) was copied by the Umbrella Company laboratory and became a research specimen for Dr. Isaac (Iain Glen). Because the DNA in her body can fight the T-virus, the doctor uses it to increase the lethality of zombies. Alice received a distress signal from humans, but was tricked and fought several times before she saved herself. She was relieved, but in her sleep, she strongly felt the call of a powerful force in her body. Obviously, the Umbrella Company laboratory had done something to her. Moreover, Dr. Isaac also injected human blood into the zombies to activate their human minds. The zombies became stronger and could not be controlled at all. They brutally killed the laboratory assistants and were trained to deal with Alice. Three years later, the earth became a barren land. The survivors in Nevada formed an alliance, and Alice was among them, but she did not dare to reveal her identity because the laboratory gave her superpowers and forced her to be a spy. Alice was isolated, and only Carlos understood her difficulties, and the two fell into ambiguity...