Umbrella Corporation, which studies biochemical weapons for the military, has a huge research center, the Hive, underground in Raccoon City. Due to an accident, a biochemical weapon that can be transmitted through the air leaked. The computer system "Red Queen" responsible for the security of the Hive initiated emergency measures, but hundreds of staff members died... Four hours later, Alice (Milla Jovovich), a security guard of the Hive, woke up at the exit of the Hive and lost her memory due to hypnotic gas. A special team ordered to shut down the Red Queen came here and teamed up with Alice, Anderson, who claimed to be a policeman, and Parks, a Hive staff member, to go deep underground. Due to the conflict between the mission objectives and the Red Queen, the group encountered successive attacks from the security system and zombies, and Alice's gradually recovered memory revealed her extraordinary connection with her companions. How can this biochemical zombie crisis be resolved? Or is it simply a prelude to despair? This film is the first in a series of films adapted from the well-known video game "Resident Evil".