The mutant Apocalypse (Oscar Isaac) was born at the very beginning of human civilization and was worshipped as a god by humans. However, he was betrayed by the humans he despised the most and was buried under the ruins and rubble. Thousands of years passed in a blink of an eye. An accident caused Apocalypse, who had been sleeping for thousands of years, to wake up from chaos. When he returned to the world, he found that the once noble mutants were now in a very bad situation. In order to create a new world for mutants, he found Storm (Alexandra Shipp), Psylocke (Olivia Munn), Angel (Ben Hardy), and Magneto (Michael Fassbender), who wanted to live an ordinary life but was still expelled by humans, to form the Four Horsemen of Apocalypse. After sensing the movement of apocalypse, Professor X (James McAvoy) led Mystique (Jennifer Lawrence), Beast (Nicholas Hoult) and Phoenix (Sophie Turner) and others, vowed to crush the conspiracy of apocalypse.